Relationship Between Oxytocin Level, Trust, and Attachment in Individuals With Borderline Personality Disorder

State University of New York - Upstate Medical University

Status

Not yet enrolling

Conditions

Borderline Personality Disorder

Treatments

Other: Childhood Trauma Questionnaire

Other: Neuro-economical game

Other: Emotional Sensitivity test

Other: baseline serum oxytocin levels

Other: demographic questionnaire

Other: Relationships Questionnaire

Study type

Observational

Funder types

Other

Identifiers

NCT06045650

2060971

Details and patient eligibility

About

We aim to assess the baseline oxytocin levels in individuals with borderline personality disorder and correlate those levels with social behavior, and compare the results with controls.

Primary Hypothesis (H1):

There is a significant difference in trust-related behavior as measured by oxytocin (OXT) levels between borderline personality disorder (BPD) patients and healthy controls.

Secondary Hypotheses:

H2: The trust-related behavior in BPD patients is significantly influenced by their level of emotional sensitivity. Specifically, higher emotional sensitivity in BPD patients is associated with lower trust-related behavior and vice-versa.

H3: There is a significant correlation between trust-related behavior and childhood trauma in BPD patients. BPD patients with higher levels of reported childhood trauma will exhibit lower trust-related behavior compared to those with lower levels of trauma.

H4: Trust-related behavior in BPD patients varies depending on their attachment styles. Specifically, BPD patients with insecure attachment styles will exhibit lower trust-related behavior compared to those with secure attachment styles.

H5: There is a significant correlation between trust-related behavior and BPD severity. Patients with more severe BPD symptoms will exhibit lower trust-related behavior compared to those with less severe symptoms.

H6: The levels of OXT in BPD patients will significantly correlate with their reported levels of emotional sensitivity, childhood trauma, attachment styles, and BPD severity.

These hypotheses aim to address the complexities surrounding the modulation of trust-related behavior by oxytocin in BPD patients, taking into account various factors like emotional sensitivity, childhood adversity, attachment styles, and BPD severity. By testing these hypotheses, the study aims to provide a comprehensive understanding of the interplay between these factors in influencing trust-related behavior in BPD patients.

Enrollment

92 estimated patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Individuals with borderline personality disorder will qualify as cases
controls will be age, gender matched individuals without any psychiatric/mental health concerns

Exclusion criteria

for all: pregnancy, hormonal or neurological disorders, and any kind of regular medication
additional exclusion criteria for cases: a lifetime diagnosis of schizophrenia, schizoaffective disorder, bipolar disorder, or significant neurological disease, current alcohol/ drug dependence
for controls: MacLEan screening instrument for BPD will be used at the time of screening to exclude BPD diagnosis in controls