Relationship Between Post-Intubation Tracheal Stenosis and Covid-19

Ankara City Hospital

Status: Completed

Conditions: COVID-19; Post-Intubation Subglottic Stenosis; Tracheal Stenosis; Intensive Care Unit

Treatments: Procedure: tracheal stenosis follow-up file

Study type: Observational

Funder types: Other

Identifiers

NCT05682651

E.Kurul-E1-22-3142

Details and patient eligibility

About

Tracheal stenosis (TS) is a serious complication that occurs in approximately 6-22% of patients due to prolonged endotracheal intubation. Cuff hyperinflation of the endotracheal tube, use of large tubes, advanced age, female gender, smoking, obesity, and diabetes are risk factors for TS. The most common and serious complication in COVID-19 patients is acute respiratory distress syndrome (ARDS), which requires oxygen and ventilation treatments. In the literature, it is reported that 9.8-15.2% of patients need invasive mechanical ventilation (IMV). The concern of aerosol formation and prone position applications that emerged with the coronavirus pandemic caused delays in tracheostomy decisions and the use of uncontrolled high cuff pressures, paving the way for TS. The capillary perfusion pressure of the tracheal mucosa ranges from 20 to 30 mmHg. A cuff pressure of the endotracheal tube above 30 mmHg causes mucosal ischemia. Cartilage inflammation due to ischemic injury may be partial or full thickness. Depending on the degree of inflammation in the affected tracheal segments, stenosis and even perforation may develop.

It is aimed to determine the etiological causes, to determine how much of the total TS cases covid-related TS constitutes, to examine the treatments and patient results in covid/non-covid TS.

This study will contribute to the measures that can be taken during and after the care process in the intensive care unit.

Enrollment: 101 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients older than 18 years

Exclusion criteria

• Patients undergoing surgical procedures for malignancy

Trial design

101 participants in 2 patient groups

Tracheal Stenosis with Covid-19

Description:

Patients' age, gender, American Society of Anesthesiologists (ASA) classification, comorbidities, etiologic cause, intubation time, type of surgery, length of hospital stay, and morbidity/mortality information will be recorded.

Treatment:

Procedure: tracheal stenosis follow-up file

Tracheal Stenosis with Non-Covid-19

Description:

Patients' age, gender, American Society of Anesthesiologists (ASA) classification, comorbidities, etiologic cause, intubation time, type of surgery, length of hospital stay, and morbidity/mortality information will be recorded.

Treatment:

Procedure: tracheal stenosis follow-up file