Relationship Between Pre-induction Electroencephalogram Pattern of Adult Patients and Their Sensitivity to Propofol

Seoul National University

Status: Completed

Conditions: Propofol Overdose of Undetermined Intent

Treatments: Device: EEG monitoring; Drug: Propofol

Study type: Observational

Funder types: Other

Identifiers

NCT04520503

pre-induction EEG

Details and patient eligibility

About

The induction dose of propofol is generally determined based on patients' characteristics, underlying disease, general condition, and also by clinician's experiences. However, It is difficult to anticipate and objectively calculate an adequate dose of propofol for every patient considering the variability of an individual's response to propofol. If there is a specific pattern in EEG prior to induction of anesthesia that can provide information about the patient's susceptibility to propofol, every induction may be performed far more smoothly with a precisely optimized dose of propofol for each patient. The study is to find a relationship between the pre-induction EEG pattern of adult patients and their sensitivity to propofol.

Enrollment: 70 patients

Sex: All

Ages: 20 to 89 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients undergoing general anesthesia

Exclusion criteria

• Patients undergoing cardiac or brain surgery
• Patients with neurological deficit or impaired communication (Glasgow Coma Scale < 15)
• Unstable vital sign (cardiogenic, hemorrhagic, septic shock)
• Patients with eclampsia
• Patients who administered preoperative anxiolytics
• Patients who do not require intubation
• Patients who are considered unsuitable for the study

Trial design

70 participants in 1 patient group

Pre EEG group

Description:

This cohort includes all participants in this study. EEG sensor will be attached to the patient's forehead before induction of anesthesia. Patterns of EEG and data will be obtained

Treatment:

Device: EEG monitoring

Drug: Propofol