Relationship Between PTEN and Glycemic Variability and Outcome in Critically Ill Patients (GLUPTEN)

University of Roma La Sapienza

Status: Completed

Conditions: Hyperglycemia; Critical Illness

Study type: Observational

Funder types: Other

Identifiers

NCT01796847

LAVPTEN

Details and patient eligibility

About

Glycemic variability in critically ill patients is a recognized negative prognostic factor. The molecular mechanisms determining inter-patients variability in glucose metabolism during stress are not fully understood. The Phosphatase and Tensin homolog (PTEN) is known to influence glucose homeostasis by interfering in intracellular insulin signaling.

Aim of this study is to ascertain whether differential expression of PTEN in critically ill patients correlates with glycemic variability and clinical outcome.

Enrollment: 20 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• trauma
• provision informed consent

Exclusion criteria

• diabetes
• impaired fasting glucose levels

Trial design

20 participants in 1 patient group

PTEN, hyperglycemia