Relationship Between Rheumatoid Arthritis Severity and Cognition in the Elderly: The Role of Nociplastic Pain

Ahram Canadian University

Status: Enrolling

Conditions: Rheumatoid Polyarthritis; Rheumatic Diseases; Rheumatoid Arthritis

Treatments: Other: Questionnaire and physical assessments

Study type: Observational

Funder types: Other

Identifiers

NCT05934721

012/282023062023

Details and patient eligibility

About

this study aims to determine if nociplastic pain mediates the relationship between rheumatoid arthritis (RA) severity and cognitive impairment in geriatric patients 100 patients aged 65-90 years with long-standing RA and assess their disease severity, cognition, and pain sensitization will be recruited. Expectations that patients with more severe RA will have worse cognitive function, and that this relationship will be mediated by higher levels of nociplastic pain.

Enrollment: 100 estimated patients

Sex: All

Ages: 65 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 65-90 years
• diagnosed with RA for 10-30 years
• meet ACR/EULAR 2010 criteria

Exclusion criteria

• Other inflammatory arthritides
• dementia
• severe depression
• recent corticosteroid or immunosuppressant use

Trial design

100 participants in 1 patient group

RA patients aged 70-90 years

Description:

Patients meeting inclusion/exclusion criteria will be recruited from rheumatology clinics and community sources.

Treatment:

Other: Questionnaire and physical assessments