Relationship Between Serotonin and Brain Response to Social Dominance and Emotion Perception. (SERODOM)

Civil Hospices of Lyon

Status

Completed

Conditions

Healthy Volunteers

Treatments

Device: PET-fMRI scan

Study type

Interventional

Funder types

Other

Identifiers

NCT03041870

69HCL16_0014

2016-A01588-43 (Other Identifier)

Details and patient eligibility

About

Previous studies have already revealed the involvement of the serotoninergic system in the social behavior process. For example, more serotonin (5HT) was found in dominant male adult monkeys. Little is known about the serotoninergic implication in human's social behavior. The project aims to clarify the role of the serotoninergic system in social behavior in relation to the process of social hierarchical information. In order to determine how serotoninergic system is involved, the investigator will use a new technic TEP-fMRI. This technic allows us to measure the brain activity and the serotoninergic transporter occupancy (using the [C11]-DASB) at the same time. The current study aims to investigate whether serotonin transporter (5-HTT) activity correlates with the neural response (BOLD) during the detection of social dominance in facial expressions or other measures of social information processing. Blood sample, SLC6A4 (allele coding for the 5HT transporter) genotyping and neuropsychological questionnaires will give at the investigator more information and allow to investigate whether performance on social information processing is modulated by personality trait and genotype.

Enrollment

34 patients

Sex

Male

Ages

18 to 45 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

French speaking
Normal vision
Age from 18 to 45
Without psychiatric antecedent
Without any neurologic antecedent
Not taking psychotropic or anxiolytic drugs
Having health insurance coverage

Exclusion criteria

The subject does not wish to be notified of any anomalies detected during MRI
Subjects suffering from claustrophobia
Subjects carrying magnetic metal objects that cannot be removed as cochlear implant, surgical clips, piercings, pacemakers, mechanical valves
Subjects participating in a clinical trial or being in a period of exclusion from a previous clinical trial
Person under guardianship or curatorship or deprived of liberty or in emergencies
Taking unauthorized treatment in the month before the completion of the review
Person whose physical or mental condition does not allow him to pass the test study