Relationship Between Serum Vitamin D and Atherosclerosis in Hemodialysis Patients

Ain Shams University

Status: Completed

Conditions: Hemodialysis; Serum; Vitamin D; Atherosclerosis

Treatments: Other: Measurement of Carotid Intima-Media Thickness; Diagnostic Test: Measurement of Serum Vitamin D Level

Study type: Observational

Funder types: Other

Identifiers

NCT07200804

FMASU MSO 2/2025

Details and patient eligibility

About

The study aimed to check if there is a link between good vitamin D levels in the blood and subclinical atherosclerosis in people on hemodialysis.

Full description

Hemodialysis patients with End-Stage Renal Disease (ESRD) face a significantly elevated risk of cardiovascular disease (CVD) due to a complex interplay of factors. A 30-year-old HD patient faces a cardiovascular mortality risk equivalent to that of an 80-year-old in the general population, emphasizing the accelerated aging of the cardiovascular system in ESRD.

Vitamin D may reduce inflammation and modulate immunity, lowering hypertension and dyslipidemia risks and possibly reversing vascular calcification. However, excessive supplementation can cause hypercalcemia.

Enrollment: 90 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with end-stage renal disease (ESRD) who had been on maintenance hemodialysis for at least 6 months.
• Age of 18 years or older.
• Patients receiving three weekly dialysis sessions using a bicarbonate-based dialysate with anticoagulants.

Exclusion criteria

• Patients with active infections, malignancies, autoimmune diseases, or pre-existing cardiovascular conditions.
• Pregnancy.

Trial design

90 participants in 2 patient groups

Group A

Description:

Patients with normal carotid intima-media thickness (CIMT).

Treatment:

Diagnostic Test: Measurement of Serum Vitamin D Level

Group B

Description:

Patients with increased carotid intima-media thickness (CIMT).

Treatment:

Other: Measurement of Carotid Intima-Media Thickness