Relationship Between Spinopelvic Parameters and Clinical Symptoms of Low-grade Lumbar Isthmic Spondylolisthesis

Peking University

Status: Completed

Conditions: Isthmic Spondylolisthesis

Treatments: Radiation: PI-LL

Study type: Interventional

Funder types: Other

Identifiers

NCT04968626

M2019125

Details and patient eligibility

About

This was a retrospective study.PI and LL greatly influence IS and its progression. However, relationships between the spinopelvic parameters and clinical symptoms of patients with IS were not fully investigated in previous studies. Investigators hypothesized that spinopelvic parameters might be related to the clinical symptoms of IS patients. Therefore, the purpose of the present study was to investigate whether differences in spinopelvic parameters, especially spinopelvic alignment, may be associated with the clinical symptoms of low-grade IS patients.

Full description

Isthmic spondylolisthesis (IS) is one of the most common types of spondylolisthesis, and spinopelvic parameters are closely related to the clinical symptoms of spinal diseases. In this study, investigators attempted to investigate the relationship between spinopelvic parameters and clinical symptoms of patients with low-grade (Meyerding grade I-II) isthmic spondylolisthesis (IS).

A total of 120 patients with low-grade IS and 106 asymptomatic adults were included in this study. Sex, age and body mass index (BMI) were also collected. Various spinopelvic parameters were evaluated in whole-spine standing-position X-rays. The following spinopelvic parameters were measured: pelvic incidence (PI), sacral slope (SS), pelvic tilt (PT) and lumbar lordosis (LL). The clinical symptoms of the IS patients were assessed with the Japanese Orthopaedic Association (JOA) score and the visual analogue scale (VAS). Investigators compared spinopelvic parameters between the asymptomatic adults and the IS patients. Additionally, investigators investigated correlations between spinopelvic parameters and clinical symptoms.

Enrollment: 226 patients

Sex: All

Ages: 54 to 76 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• isthmic spondylolisthesis subjects had spondylolisthesis at L4 or L5 (Meyerding grade I-II) with whole-spine standing lateral images

Exclusion criteria

• spondylolisthesis of other types (Degenerative, dysplastic, etc.);
• Lumbar infection and/or tumor diseases;
• A previous history of lumbar fusion surgery.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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226 participants in 2 patient groups

IS GROUP

Experimental group

Description:

Patients who received an operation to treat their isthmic spondylolisthesis (IS, Meyerding grade I-II)

Treatment:

Radiation: PI-LL

AS GROUP

No Intervention group

Description:

The asymptomatic adults had no history of severe back pain or spinal trauma