Relationship Between Systemic Fatty Acid Availability and Insulin Sensitivity

University of Michigan

Status: Completed

Conditions: Obesity

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT01452048

R01 DK077966 - OC

R01DK077966 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The investigators specific aim is to compare the relationship between systemic fatty acid availability and insulin sensitivity in a relatively homogenous population of obese adults. The investigators anticipate 1) greater systemic fatty acid availability will be associated with lower insulin sensitivity and 2) greater systemic fatty acid availability will be associated with greater accumulation of fatty acid intermediates and pro-inflammatory markers.

Enrollment: 38 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Body mass index [BMI]: 35-45 kg/m2; All women must be pre-menopausal; Non-exerciser (no regularly planned exercise/physical activity)

Exclusion criteria

• Weight instability ≥ ±5 lbs. in past month; medications known to affect lipid and/or glucose metabolism; Pregnancy or actively breast feeding

Trial design

38 participants in 1 patient group

Obese Sedentary Adults, but otherwise healthy