Relationship Between Topiramate Use and Ocular Angle Status

The Chinese University of Hong Kong

Status and phase: Unknown; Phase 4

Conditions: Glaucoma, Angle-Closure

Treatments: Drug: Topiramate

Study type: Interventional

Funder types: Other

Identifiers

NCT00153699

CRE-2004.310

Details and patient eligibility

About

We test the hypothesis whether topiramate narrows the angles which may render Asians more likely to suffer from acute angle closure glaucoma.

Full description

Topiramate is approved for the treatment of epilepsy and prophylaxis of migraine attacks. There were case reports of acute angle closure glaucoma (AACG) associated with its use. AACG is particularly common in Asians because of a higher prevalence of narrow angle., we test the hypothesis whether topiramate narrows the angles which may render them more likely to suffer from AACG.

Enrollment: 15 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Participants aged 18-75 with an indication for starting topiramate.

Exclusion criteria

• Patients with known allergy or intolerance to topiramate.
• Recent exposure to topiramate (<3 months).
• Moderate to severe renal failure.
• Known history of renal calculi or hepatic failure
• Inability to give informed consent.
• Pregnant women or women of child-bearing age who do not practise an acceptable means of contraception.
• Patients known to have angle-closure glaucoma.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)