Relationship Between Vitamin D and Vitamin B12 Levels and Neuropathic Pain in Lipedema

Fatih Sultan Mehmet Training and Research Hospital

Status

Active, not recruiting

Conditions

Lipedema

Vitamin D Deficiency

B12 Deficiency Vitamin

Treatments

Other: Vitamin B12 Level

Study type

Observational

Funder types

Other

Identifiers

NCT06338059

Gulcanozturkchatipchousein

Details and patient eligibility

About

Lipedema is a disease characterized by bilateral abnormal fat deposition in the upper and lower extremities. Pain is a common symptom in lipedema.Vitamin D plays an important role in chronic pain. Vitamin B have analgesic role in some neuropathic pain conditions.This study aimedto evaluate the relationship between vitamin D and vitamin B12 levels and neuropathic pain in lipedema.

Full description

In this cross sectional study 200 lipedema patients will beincluded. According to painDETECT questionnaire scores of cases with lipedema patients will be divided into two groups;An overall score of > 13 likely or possible neuropathic pain (group 1) and <13 unlikely NP (group 2). Patients' age, gender, comorbid diseases and laboratory values (25 OH vitamin D and vitamin B12 levels) will be recorded.

Enrollment

200 patients

Sex

Female

Ages

18 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

The patients diagnosed byan experienced physical medicine and rehabilitation specialist for the diagnosis of lipedema

Exclusion criteria

individuals who did not have 25(OH)D and B12 values in the past 6 months,
those with a history of gastrectomy or bypass surgery,
those consuming a vegetarian diet, those with lymphedema or chronic venous insufficiency, endocrine diseases, rheumatic diseases, malignancy, neurological diseases, and musculoskeletaldiseases that can be related to lower extremity neuropathic or nociceptivepain.