Relationship of Cerebral Perfusion Pressure Variability to Sepsis-associated Encephalopathy

Kang Yan

Status: Completed

Conditions: Sepsis

Treatments: Other: no interventions

Study type: Observational

Funder types: Other

Identifiers

NCT02288715

CPPV-KYan1205

Details and patient eligibility

About

The purpose of the study is to evaluate whether variability of CPP (cerebral perfusion pressure) is related to sepsis-associated encephalopathy and outcomes of patients with sepsis.

Full description

Encephalopathy is a common complication of sepsis, impaired cerebrovascular autoregulation (AR) in patients with sepsis is considered related to Sepsis-associated encephalopathy (SAE). As AR is important in stabilizing the cerebral perfusion pressure, whether greater variability of CPP is related to SAE and mortality or not remains unclear. We conduct this study to evaluate the relationship between them.

Enrollment: 110 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• clinical symptoms of sepsis, severe sepsis and septic shock
• age over 18 years

Exclusion criteria

• preexisting Neurological diseases
• traumatic brain injury
• intracranial infectious disease
• severe hepatic or renal dysfunction
• ICU discharge Within 72 hours
• pregnancy

Trial design

110 participants in 2 patient groups

SAE

Description:

patient who develop encephalopathy in the progress of sepsis

Treatment:

Other: no interventions

non-SAE

Description:

patient who do not develop encephalopathy in the progress of sepsis

Treatment:

Other: no interventions