Relationship of Endoplasmic Reticulum Stress and Tonsillar Tissue Diseases

Selcuk University

Status: Completed

Conditions: Immune System Diseases; Tonsillitis; Tonsillar Hypertrophy

Treatments: Procedure: Tonsillectomy surgery

Study type: Observational

Funder types: Other

Identifiers

NCT04653376

2018/329

Details and patient eligibility

About

Tonsillar tissue is a significant organ for the performing of immune systems in children. The Endoplasmic Reticulum (ER), is an organelle needed for the care of a stable function of the cells. The purpose of the study was to explore the correlation among ER stress and tonsillar tissue disorders and to explain the structure of diseases related to the immune system.

Full description

A prospective study was conducted on 46 children aged who underwent tonsillectomy for chronic tonsillitis or tonsil hypertrophy. Tonsil tissues were evaluated in terms of ER stress markers and apoptosis markers by Real-time PCR and Western blot methods.

Enrollment: 46 patients

Sex: All

Ages: 2 to 16 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who underwent tonsillectomy surgery with the clinical diagnosis of chronic tonsillitis and tonsillar hypertrophy.

Exclusion criteria

• Systemic diseases
• Other otolaryngological disorders

Trial design

46 participants in 2 patient groups

Chronic tonsillitis

Description:

Patients with tonsil sizes grade 1 and 2, and tonsillectomy indications included frequently recurrent tonsillary infection, sore throat, and malodorous mouth problems were accepted as the chronic tonsillitis group.

Treatment:

Procedure: Tonsillectomy surgery

Tonsillar hypertrophy

Description:

Patients with tonsil size grades 3 and 4 and tonsillectomy indications included obstructive symptoms such as snoring, open mouth breathing, difficulty in breathing, and swallowing problems were accepted as the tonsillar hypertrophy group.

Treatment:

Procedure: Tonsillectomy surgery