Relationship of Genes and Life Events to Blood Pressure

Sunnybrook Health Sciences Centre

Status: Completed

Conditions: Hypertension; Psychosocial Factors

Treatments: Genetic: Cheek swab samples for DNA

Study type: Observational

Funder types: Other

Identifiers

NCT00327431

1000009109

Details and patient eligibility

About

Research suggests that blood pressure is influenced by both genetic and environmental factors. The goal of this study is to find genes that play a role in blood pressure and understand how they interact with life events (such as job stress) to influence blood pressure. We hypothesize that the gene for endothelin-1 is associated with increased blood pressure. Further, we predict that this genetic relationship is moderated by psychosocial stress factors, specifically job strain and marital cohesion.

Enrollment: 120 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Previous participation in a study of psychosocial stressors and blood pressure (Double Exposure Study) and agreement to participate in follow-up studies

Exclusion criteria

• Withdrawal of consent