Relationships Between Exercise and Appetite in Women With Loss of Control Eating

Ohio University

Status: Enrolling

Conditions: Binge-Eating Disorder; Bulimia Nervosa; Eating Disorders

Treatments: Behavioral: Fed Exercise; Behavioral: Fasted Exercise; Behavioral: Rest

Study type: Interventional

Funder types: Other

Identifiers

NCT06602973

IRB_FY24-403

Details and patient eligibility

About

This pilot study is a first step in looking at the relationship between exercise and appetite in women with loss of control eating.

Enrollment: 26 estimated patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Engage in loss of control eating at least 12 times in the last three months
• Clinically significant eating disorder-related impairment (CIA > 15)
• Taking hormonal contraception
• Minimum VO2max of 50th percentile for age and sex assigned at birth
• Be willing to eat study-provided foods
• Likes chocolate (at least 6/10 on 10 point scale)

Exclusion criteria

• BMI < 18.5 kgm/2
• Medical conditions that affect appetite or weight (e.g., diabetes mellitus, thyroid disease)
• Recent pregnancy or breastfeeding (prior 6 months)
• Relevant food allergies (e.g., wheat, chocolate)
• Specific phobia, blood-injection-injury type
• Medical condition that precludes safe participation in exercise (e.g., stress fracture)
• Medications that acutely affect appetite (e.g., GLP-1 agonists; psychiatric medications allowed)

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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26 participants in 6 patient groups

Rest, Fed Exercise, Fasted Exercise

Experimental group

Description:

At Study Visit 2, participants will eat breakfast and rest (abstain from exercise). At Study Visit 3, participants will eat breakfast and exercise. At Study Visit 4, participants will abstain from breakfast and will engage in exercise.

Treatment:

Behavioral: Rest

Behavioral: Fasted Exercise

Behavioral: Fed Exercise

Rest, Fasted Exercise, Fed Exercise

Experimental group

Description:

At Study Visit 2, participants will eat breakfast and rest (abstain from exercise). At Study Visit 3, participants will abstain from breakfast and will engage in exercise. At Study Visit 4, participants will eat breakfast and exercise.

Treatment:

Behavioral: Rest

Behavioral: Fasted Exercise

Behavioral: Fed Exercise

Fed Exercise, Rest, Fasted Exercise

Experimental group

Description:

At Study Visit 2, participants will eat breakfast and exercise. At Study Visit 3, participants will eat breakfast and rest (abstain from exercise). At Study Visit 4, participants will abstain from breakfast and will engage in exercise.

Treatment:

Behavioral: Rest

Behavioral: Fasted Exercise

Behavioral: Fed Exercise

Fed Exercise, Fasted Exercise, Rest

Experimental group

Description:

At Study Visit 2, participants will eat breakfast and exercise. At Study Visit 3, participants will abstain from breakfast and will engage in exercise. At Study Visit 4, participants will eat breakfast and rest (abstain from exercise).

Treatment:

Behavioral: Rest

Behavioral: Fasted Exercise

Behavioral: Fed Exercise

Fasted Exercise, Fed Exercise, Rest

Experimental group

Description:

At Study Visit 2, participants will abstain from breakfast and will engage in exercise. At Study Visit 3, participants will eat breakfast and exercise. At Study Visit 4, participants will eat breakfast and rest (abstain from exercise)

Treatment:

Behavioral: Rest

Behavioral: Fasted Exercise

Behavioral: Fed Exercise

Fasted Exercise, Rest, Fed Exercise

Experimental group

Description:

At Study Visit 2, participants will abstain from breakfast and will engage in exercise. At Study Visit 3, participants will eat breakfast and rest (abstain from exercise). At Study Visit 4, participants will eat breakfast and exercise.

Treatment:

Behavioral: Rest

Behavioral: Fasted Exercise

Behavioral: Fed Exercise