Relationships Between Tenascin C, Smoking and Periodontal Status

Necmettin Erbakan University

Status: Not yet enrolling

Conditions: Periodontitis; Periodontal Diseases; Smoking

Treatments: Diagnostic Test: Clinical Measurements and Saliva Sample Collection

Study type: Observational

Funder types: Other

Identifiers

NCT06523205

tenascincsmokeperiodontitis

Details and patient eligibility

About

The goal of this observational study is to determine if there is a relationship between different periodontal conditions (gingival healthy, stage 2 grade B, stage 2 grade C, stage 3 grade B, stage 3 grade C) and the levels of tenascin C, IL-1 beta, IL-4, and IL-6 in saliva samples from smokers and non-smokers. The main questions it aims to answer are:

Is there a difference in the levels of tenascin C, IL-1 beta, IL-4, and IL-6 between smokers and non-smokers with different periodontal conditions? Do these biomarkers correlate with the severity and grade of periodontal disease?

Researchers will compare the saliva samples from smokers and non-smokers across the different periodontal conditions to see if there are significant differences in the biomarker levels. Participants will:

Provide saliva samples. Be categorized based on their smoking status and periodontal condition.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• The periodontitis groups (Non-smoking and smoking) in the study will include systemically healthy patients who are clinically diagnosed with Stage II and III, generalized, Grade B, C periodontitis based on the consensus report of the 2017 World Workshop on Classification of Periodontal and Peri-Implant Diseases and Conditions.
• Agreeing to participate in the study

Exclusion criteria

• use of oral contraceptive drugs
• use of antibiotics, immunosuppressants, or drug therapies in the last 6 months before the study;
• history of excessive alcohol use;
• pregnancy or breastfeeding status;
• periodontal treatment during the last 6 months before the study.
• Not agreeing to participate in the study
• Not meeting the inclusion criteria

Trial design

100 participants in 4 patient groups

non-smoking - periodontally healthy

Description:

participants who reported never smoking and periodontal healthy.

Treatment:

Diagnostic Test: Clinical Measurements and Saliva Sample Collection

smoking - periodontally healthy

Description:

participants who reported smoking \>10 cigarettes per day and periodontal healthy.

Treatment:

Diagnostic Test: Clinical Measurements and Saliva Sample Collection

non-smoking - periodontitis

Description:

participants who reported never smoking, with clinical attachment loss ≥3 mm in \>30% of sites, with probing depth ≥5 mm in at least six teeth, and with radiographic bone loss extending to or beyond the middle third of the root in the coronal third will be included.

Treatment:

Diagnostic Test: Clinical Measurements and Saliva Sample Collection

smoking - periodontitis

Description:

participants who reported smoking \>10 cigarettes per day for \>5 years with clinical attachment loss ≥3 mm in \>30% of sites, with probing depth ≥5 mm in at least six teeth, and with radiographic bone loss extending to or beyond the middle third of the root in the coronal third will be included.

Treatment:

Diagnostic Test: Clinical Measurements and Saliva Sample Collection