Relationships of B-cell Activating Factor Gene Polymorphisms With Crohn's Disease.

Second Affiliated Hospital of Wenzhou Medical University

Status: Completed

Conditions: Crohn Disease

Study type: Observational

Funder types: Other

Identifiers

NCT07387172

SAHoWMU-CR2026-01-201

Details and patient eligibility

About

From January 2020 to December 2024, Crohn's disease(CD) patients and gender- and age-matched normal controls were collected from the Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University. The aim of this research is to explore the associations of B-cell activating factor(BAFF) gene polymorphisms with the risk and clinicopathological characteristics of CD.

Full description

From January 2020 to December 2024, a total of 310 CD patients and 514 gender- and age-matched normal controls were collected from the Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University.The genotypes of BAFF were determined by multiplex polymerase chain reaction-ligase detection reaction technique. Unconditional logistic regression was employed to analyze the distribution of BAFF gene polymorphisms between CD group and normal control group, as well as their influences on the clinicopathological characteristics of CD patients.

Enrollment: 824 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• diagnosed CD based on comprehensive clinical, colonoscopy, histopathological, laboratory, and radiographic examination results

Exclusion criteria

• rheumatoid arthritis, systemic lupus erythematosus, intestinal tuberculosis, ischemic enteritis, radiation enteritis, tumors, etc

Trial design

824 participants in 2 patient groups

CD patients

Description:

Patients diagnosed with Crohn's disease

normal controls

Description:

gender- and age-matched normal controls