Status and phase
Conditions
Treatments
About
This study is an open-label, 3-way crossover randomized study in adult healthy volunteers to evaluate the relative bioavailability of TT-00420 tablet and capsule formulations and to evaluate food effect on the pharmacokinetics of TT-00420 tablet.
Full description
Subjects will be randomized to one of three treatment sequences. Each sequence will contain up to 8 subjects. In each treatment sequence, subjects undergo a baseline/screening period, three treatment periods, and a follow-up visit.
Subjects will be administered a single dose of TT-00420 on Day 1 of either TT-00420 tablet under fed condition, TT-00420 tablet under fasting condition, or capsule under fasting condition and crossed over after at least a 14-day washout period.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
Male or female subjects between 18 and 64 years of age inclusive, at the time of signing the informed consent.
Body mass index (BMI) between 18 and 32 kg/m2, inclusive, and weighs at least 50 kg.
Healthy as determined by the investigator based on medical history, clinical laboratory results (serum chemistry, hematology, urinalysis, and serology), vital sign measurements, 12-lead electrocardiogram (ECG) results, and physical examination findings. A subject with a clinical abnormality or laboratory parameters outside the reference range for the population being studied may be included only, if per the investigator discretion, the investigator judges and documents that the finding is unlikely to introduce additional risk factors and will not interfere with the study procedures.
Male subjects must not donate sperm starting at Screening, throughout the study period and for at least 90 days after final study drug administration.
Male subjects with female sexual partner(s) of reproductive potential may be enrolled if the male:
If female, is of non-childbearing potential, meeting the following requirements:
Able to sign the informed consent and comply with the protocol.
Exclusion criteria
Any history of clinically serious disease.
Any active or unstable clinically significant medical condition as judged by the Investigator.
History or presence of gastrointestinal, hepatic or renal disease, or any other condition known to interfere with absorption, distribution, metabolism, or excretion of drugs
Hypersensitivity or allergy to any of the study drugs or drugs of similar chemical classes.
Hypersensitivity or allergy for components of the prescribed meal
Received any investigational drug within 30 days or 5 half-lives(whichever is longer, if known) before the study.
Subject who has undergone major surgery ≤ 2 months before study drug administration.
Impaired cardiac function including clinically significant arrhythmias or clinically significant abnormality in clinical test, including but not limited to any of the following at Screening and Admission, repeat testing is allowed for verification, at the discretion of the Investigator:
Subject who has a known history of, or a positive test result for, hepatitis B surface antigen (HBsAg), immunoglobulin M (IgM) antibody to hepatitis B core antibody (anti-HBc) (IgM anti-HBc), hepatitis C virus antibody (anti-HCV), or human immunodeficiency virus (HIV) types 1 or 2, or syphilis at Screening.
Subject with a history of severe visual diseases; or visual changes including flushing lights, blurry vision, color changes, or other visual changes.
Subject who has used prescription or over-the-counter (OTC) medication (other than ≤ 2 g/day paracetamol [acetaminophen] or ≤ 800-mg/day ibuprofen), vitamins, or herbal remedies, within 2 weeks or 5 half-lives (if known) before study drug administration, whichever is longer.
Subject who has had a loss of more than 100 mL blood (e.g., a blood donation) within 2 months before study drug administration, or has received any blood, plasma, or platelet transfusions within 3 months before Admission, or plans to donate blood during the study or within 3 months after the study.
Subject who has a history of alcohol abuse (defined as an alcohol intake more than 21 units for males and 14 units for females per week) or a history of drug abuse within the 6 months before study drug administration, or a history of substance abuse deemed significant by the Investigator.
Subject who smokes cigarettes or uses other nicotine-containing products (e.g., snuff, nicotine patch, nicotine chewing gum, mock cigarettes, or inhalers), and has done so in the 3 months prior to Screening.
Subject who has a positive test for alcohol or drugs of abuse (opiates, methadone, buprenorphine, methamphetamine, cocaine, cannabinoids, amphetamines, or cotinine) at Screening or Admission.
Subject is unable to complete this study for other reasons or the Investigator believes that he or she should be excluded.
Primary purpose
Allocation
Interventional model
Masking
24 participants in 3 patient groups
Loading...
Data sourced from clinicaltrials.gov
Clinical trials
Research sites
Resources
Legal