Relative Importance of Cardiovascular Risk Factors and Echocardiographic Parameters Affecting Left Atrial Strain (RICH-LAST)

Yonsei University

Status: Enrolling

Conditions: Heart Failure, Diastolic; Heart Failure, Preserved Ejection Fraction

Treatments: Diagnostic Test: Left atrial reservoir strain

Study type: Observational

Funder types: Other

Identifiers

NCT05638230

9-2022-0101

Details and patient eligibility

About

The goal of this observational study is to learn about left atrial reservoir strain in patients with heart failure with preserved ejection fraction. The main questions it aims to answer are:

• Usefullness of LARS as a predictor of high HFA-PEFF diagnostic algorithm scores (≥5)
• The relative importance of LARS in variables including each component of HFA-PEFF and traditional cardiovascular risk factors.

Enrollment: 2,500 estimated patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Participants with ICD-10 code of heart failure (I50) from August 2021 to July 2022
• 20-year-old or higher age
• Participants who are available to measure left atrial reservoir strain

Exclusion criteria

• Left ventricular ejection fraction <50%
• Supraventricular arrhythmia (e.g. atrial flutter/fibrillation, atrial tachycardia)
• Participants who are given pacemaker or ICD implantation procedure

Trial design

2,500 participants in 2 patient groups

HIgh HFA-PEFF points (≥5)

Treatment:

Diagnostic Test: Left atrial reservoir strain

Low to intermediate HFA-PEFF points (<5)

Treatment:

Diagnostic Test: Left atrial reservoir strain