Relaxation Response Training to Treat Hypertension
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Conditions
Treatments
Details and patient eligibility
About
Interventions such as Relaxation Response appear to have widespread effects on physiology. Endothelial function, changes in genomic expression, several biomarkers have been associated with chronic stress and cardiovascular dysfunction, and there is some suggestion that elicitation of the Relaxation Response may lead to improvement in-or normalization of-these factors. By studying the impact of the Relaxation Response on endothelial function, genomic expression and biomarkers among subjects with hypertension, it may be possible to better understand the biologic underpinnings of Relaxation Response-type interventions. Furthermore, with a greater understanding of the physiologic mechanisms by which the Relaxation Response works, it may be possible to better target other symptoms and conditions that can be effectively treated by such an intervention.
Enrollment
Sex
Ages
Volunteers
Inclusion and exclusion criteria
General Inclusion Criteria:
- Healthy men and women
- Hypertension (stage 1)
- 18-70 years old
General Exclusion Criteria
- No asthma or nasal allergies
- Non-smokers
- If on anti-hypertensive medication willing to discontinue
- Cannot currently practice Tai Chi, meditation, or yoga regularly
- Current use of the following medications: phosphodiesterase type 5 inhibitors, long-acting nitrates, systemic corticosteroids, anti-inflammatories, immunosuppressive or cytotoxic therapies (currently or within the last 12 months), anabolic steroids, and antidepressants.
Trial design
Primary purpose
Allocation
Interventional model
Masking
58 participants in 1 patient group
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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