Relaxin and Placental Volume in Placenta Accreta Spectrum

Başakşehir Çam & Sakura City Hospital

Status: Completed

Conditions: Placenta Accreta / Percreta; Placenta Accreta Spectrum

Treatments: Diagnostic Test: relaxin

Study type: Observational

Funder types: Other

Identifiers

NCT06808165

KAEK/2023.01.20

Details and patient eligibility

About

This retrospective case-control study investigated the potential role of circulating relaxin levels and estimated placental volumes (EPV) in the pathogenesis and diagnosis of placenta accreta spectrum (PAS) disorders. It compared these parameters in patients diagnosed with PAS versus healthy controls.

Full description

This study aimed to compare relaxin levels in umbilical cord and peripheral blood and estimated placental volumes (EPV) between PAS cases and controls. Additionally, subgroup analysis was conducted to evaluate relaxin levels and EPV among PAS subtypes (accreta, increta, and percreta).A retrospective case-control study was conducted at a tertiary referral center, analyzing data from January 2022 to December 2022.

Enrollment: 40 patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Women aged 18-45 years Confirmed histopathological diagnosis of PAS (case group) Complete medical records Healthy pregnant women undergoing cesarean delivery (control group)

Exclusion criteria

Multifetal gestation Emergency surgeries Incomplete medical records

Trial design

40 participants in 2 patient groups

Placenta Accreta Spectrum Group

Description:

* 20 patients diagnosed with PAS, confirmed through histopathological findings post-cesarean hysterectomy * Blood and placental tissue analyzed for relaxin levels and placental volume * Subgroup analysis based on PAS severity (accreta, increta, percreta)

Treatment:

Diagnostic Test: relaxin

Control Group (No PAS Pathology with Elective Cesarean Section)

Description:

* 20 healthy pregnant women undergoing elective cesarean section * Blood and placental volume assessed

Treatment:

Diagnostic Test: relaxin