Releasing of Inflammatory Mediators During Retreatment of Root Canals

Bulent Ecevit University

Status: Completed

Conditions: Root Canal Infection; Inflammatory Response

Treatments: Other: Reciproc; Other: XP-Endo finisher R; Other: Protaper Universal Retreatment

Study type: Interventional

Funder types: Other

Identifiers

NCT05039502

2020-27194235-01

Details and patient eligibility

About

Nonsurgical root canal retreatment may become essential when the initial endodontic treatment fails because of the persistent intracanal or extracanal infections.The aim of this thesis study is to evaluate the effect of ProTaper Universal Retreatment (PTUR), Reciproc blue and XP-endo Finisher R file systems, which are used in the removal of root canal filling materials during retreatment with different motion kinetics on the release of Substance P, Calcitonin Gene-Related Peptide (CGRP), IL-6 and IL-10 inflammatory mediators in the periapical region

Full description

Seventy-five individuals with asymptomatic and chronic apical periodontitis teeth with retreatment indication were included in the study. Individuals were randomly divided into three groups according to the file system used to remove root canal filling materials (n = 25): ProTaper Universal Retreatment, Reciproc blue and XP-endo Finisher R.After the removal of the previous root canal filling materials, reshaping and disinfection of the root canals, periapical fluid samples were taken from the root tip of the teeth in all three groups. The amount of Substance P, CGRP, IL-6 and IL-10 mediators that cause pain, swelling and flare-up in periapical fluid samples were measured by ELISA test.

Enrollment: 75 patients

Sex: All

Ages: 18 to 68 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients who had single root canal treated teeth with chronic periapical lesion

Exclusion criteria

• Patients who are immunocompromised
• Patients under antibiotic or analgesic medication

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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75 participants in 3 patient groups

Retreatment system using in rotational motion

Experimental group

Description:

Previous root canal filling materials were removed with D1-D2-D3 retreatment files with using an endodontic motor in rotational motion

Treatment:

Other: Protaper Universal Retreatment

Retreatment system using in reciprocal motion

Experimental group

Description:

Previous root canal filling materials were removed with Reciproc 25 file with using an endodontic motor in reciprocal motion

Treatment:

Other: Reciproc

Retreatment system using in additional rotational motion

Experimental group

Description:

Previous root canal filling materials were removed with XP-endo finisher r file with using an endodontic motor in rotational motion

Treatment:

Other: XP-Endo finisher R