Reliability of Multiple-Repetition-Maximum Tests in Patients with Cardiovascular Disease or Risk Factors

Technical University of Munich

Status: Not yet enrolling

Conditions: Arterial Hypertension; Diabetes Mellitus; Atrial Fibrillation (AF); Heart Failure; Coronary Heart Disease (CHD)

Study type: Observational

Funder types: Other

Identifiers

NCT06796582

2025-27-S-CB

Details and patient eligibility

About

Exercise training is a cornerstone in the prevention and rehabilitation of cardiovascular disease. While research has primarily focused on endurance training, resistance training becomes more and more important. The gold standard to prescribe resistance training intensity or monitor longitudinal changes is the 1-Repetition-Maximum (1-RM) test. However, particularly for unexperienced individuals, this test may not be recommendable due to the high load and an increased risk of injuries. Alternatively, there are several published formulas to estimate the 1-RM based on a multiple-repetition-maximum (or repetition-to-failure) test. However, these formulas have been primarily tested in healthy individuals. Moreover, the reliability of the 1-RM estimation based on two tests with different submaximal weight is unknown. Therefore, the present study evaluates the agreement of the 1-RM estimation (based on different formulas) between two Multiple-RM tests with different weight in 50 patients with cardiovascular disease (heart failure, coronary heart disease, atrial fibrillation) or cardiovascular risk factors (type 2 diabetes, arterial hypertension).

Enrollment: 50 estimated patients

Sex: All

Ages: 50+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 50 years
• At least one of the following cardiovascular diseases / risk factors:
• Heart failure
• Coronary heart disease
• Atrial fibrillation
• Arterial hypertension
• Type 2 diabetes mellitus
• Clinically stable for ≥ 4 weeks
• Medical clearance to perform resistance training / strength testing
• Signed written informed consent

Exclusion criteria

• Pregnancy
• Acute infection
• Chronic joint inflammation
• Knee, hip, ankle, wrist, elbow or shoulder pain
• Known osteoporosis (T-value ≤ -2.5)
• Uncontrolled hypertension (≥160 mmHG systolic / ≥100 mmHG diastolic)
• Known cerebral or thoracic aneurysm