Remifentanil and Atropine for Intubation in Neonates (RAIN)

King Saud University

Status and phase: Completed; Phase 4

Conditions: Endotracheal Intubation

Treatments: Drug: Fentanyl/Atropine/Succinylcholine; Drug: Atropine/Remifentanil

Study type: Interventional

Funder types: Other

Identifiers

NCT00815048

RAIN

Details and patient eligibility

About

The investigators hypothesize that the use of a combination of Atropine and Remifentanil will safely facilitate non emergent intubation procedure as effectively as the protocol of Atropine, Fentanyl, and Succinylcholine.

Enrollment: 30 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Hemodynamically stable neonates of any gestational age admitted to the Neonatal Intensive Care Unit at McMaster Children's Hospital requiring an elective endotracheal intubation was anticipated.

Exclusion criteria

• Urgent intubations
• Cyanotic congenital heart lesions
• Anticipated difficult airway
• Concurrent or recently administered (within 3 hours of the procedure) intravenous opioid infusions
• Pre-existing hyperkalemia
• Family history of malignant hyperthermia
• Prior enrollment

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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30 participants in 2 patient groups, including a placebo group

Remifentanil

Active Comparator group

Description:

Atropine Remifentanil

Treatment:

Drug: Atropine/Remifentanil

Fentanyl

Placebo Comparator group

Description:

Atropine Fentanyl Succinylcholine

Treatment:

Drug: Fentanyl/Atropine/Succinylcholine