Remifentanil for Preventing Propofol Injection Pain in Elderly Patients

Ajou University School of Medicine

Status and phase: Completed; Phase 4

Conditions: Drug Usage

Treatments: Drug: Remifentanil

Study type: Interventional

Funder types: Other

Identifiers

NCT03330782

AJIRB-MED-OBS-17-197

Details and patient eligibility

About

Elderly patients show different pharmacokinetic and pharmacodynamic variables and usually need smaller doses of anesthetic drugs than younger patients. The purpose of this study was to investigate the optimal effect-site concentration of remifentanil for preventing injection pain during propofol induction in elderly patients by the Dixon's up-and-down method.

Enrollment: 52 patients

Sex: Male

Ages: 19 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA physical status I or II undergoing general anesthesia

Exclusion criteria

• neurologic disorder
• psychologic disorder
• vascular disorder
• patients with chronic pain
• difficulty in vascular access

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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52 participants in 2 patient groups

Elderly

Experimental group

Description:

Remifentanil was infused at predetermined effect-site concentration before propofol infusion in elderly patients.

Treatment:

Drug: Remifentanil

Drug: Remifentanil

Adult

Active Comparator group

Description:

Remifentanil was infused at predetermined effect-site concentration before propofol infusion in adult patients.

Treatment:

Drug: Remifentanil

Drug: Remifentanil