Remifentanil for Smooth Emergence in Elderly Patients

Ajou University School of Medicine

Status and phase: Completed; Phase 4

Conditions: Drug Usage

Treatments: Drug: Sevoflurane; Drug: Remifentanil

Study type: Interventional

Funder types: Other

Identifiers

NCT02334046

AJIRB-MED-CT4-14-383

Details and patient eligibility

About

Elderly patients show different pharmacokinetic and pharmacodynamic variables and usually need smaller doses of anaesthetic drugs than younger patients. The purpose of this study was to investigate the optimal effect-site concentration of remifentanil for preventing cough during emergence in elderly patients under sevoflurane and remifentanil anesthesia.

Enrollment: 47 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA physical status I or II undergoing endoscopic sinus surgery or septoplasty under balanced anesthesia with sevoflurane and remifentanil

Exclusion criteria

• predicted difficult airway, body mass index > 30 kg/m2, history of obstructive sleep apnoea chronic respiratory disease or coughing, current smokers patients angiotensin converting enzyme-inhibitors

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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47 participants in 2 patient groups

Elderly

Experimental group

Description:

Remifentanil was maintained at predetermined effect-site concentration during the emergence period in elderly patients.

Treatment:

Drug: Sevoflurane

Drug: Remifentanil

Drug: Remifentanil

Adult

Active Comparator group

Description:

Remifentanil was maintained at predetermined effect-site concentration during the emergence period in adult patients.

Treatment:

Drug: Sevoflurane

Drug: Remifentanil

Drug: Remifentanil