Remifentanil for the I-gel and Laryngeal Mask Airway Insertion

Ajou University School of Medicine

Status and phase: Completed; Phase 4

Conditions: Supraglottic Airways for General Anesthesia

Treatments: Drug: propofol; Drug: remifentanil; Device: i-gel; Device: laryngeal mask airway

Study type: Interventional

Funder types: Other

Identifiers

NCT02382354

AJIRB-MED-CT4-14-417

Details and patient eligibility

About

Structural differences of supraglottic airway devices could influence the different compressive forces in the oropharyngeal cavities, and require different depth of anesthesia. The addition of remifentanil during propofol anesthesia facilitates the insertion of laryngeal mask airway (LMA) with minimal adverse hemodynamic disturbances. This study was designed to determine the effect-site concentration of remifentanil in 50% of patients (EC50) and 95% of patients (EC95) for successful i- gel insertion, and compare those for LMA insertion during propofol target-controlled infusion (TCI).

Full description

Anesthesia was induced with propofol TCI at the effect-site concentration of 5 μg/ml, and the predetermined effect-site concentration of remifentanil was started simultaneously. The remifentanil concentration was determined using modified Dixon's up-and-down method (initial concentration: 3.0 ng/ml, step size: 0.5 ng/ml). Five minutes later, i- gel or LMA insertion was attempted. The response of the patients to the insertion of LMA was classified as either 'movement' or 'no movement'.

Enrollment: 41 patients

Sex: Female

Ages: 19 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA I-II patients undergoing general anesthesia for short elective surgery (<2 hr)

Exclusion criteria

• G-E reflux
• obesity (BMI>30)
• anticipated difficult airway

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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41 participants in 2 patient groups

i-gel

Experimental group

Description:

I-gel insertion was attempted during propofol and remifentanil anesthesia .

Treatment:

Device: i-gel

Drug: remifentanil

Drug: propofol

laryngeal mask airway

Active Comparator group

Description:

LMA insertion was attempted during propofol and remifentanil anesthesia .

Treatment:

Device: laryngeal mask airway

Drug: remifentanil

Drug: propofol