Remifentanil Requirement for Acceptable Intubating Condition

Ajou University School of Medicine

Status and phase: Completed; Phase 4

Conditions: Intubating Condition

Treatments: Drug: Ketamine 1; Drug: Ketamine 2; Drug: Remifentanil

Study type: Interventional

Funder types: Other

Identifiers

NCT02655380

MED-DRU-15-354

Details and patient eligibility

About

Ketamine and opioid are known to improve the intubating condition, respectively. Combination of ketamine and opioid potentiate analgesic effect and give hemodynamic stability in complementary manner. Therefore, the combination use of ketamine and remifentanil could be useful for acceptable intubating condition in the general anesthesia without the use of neuromuscular blocking agent. Generally, induction dose of ketamine ranges between 1 and 2 mg. There was no report about the optimal dose of remifentanil with 1 or 2 mg ketamine induction dose for intubation without neuromuscular blocking agent. The investigators focus on remifentanil dose using Dixon's up and down method.

Enrollment: 51 patients

Sex: All

Ages: 3 to 12 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA I-II
• Undergoing general anesthesia with endotracheal tube

Exclusion criteria

• Anticipated difficult airway
• Patient with upper respiratory infection within 14 days
• Asthma

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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51 participants in 2 patient groups

ketamine 1

Experimental group

Description:

Anesthesia induction with ketamine 1 mg followed by remifentanil.

Treatment:

Drug: Remifentanil

Drug: Ketamine 1

ketamine 2

Experimental group

Description:

Anesthesia induction with ketamine 2 mg followed by remifentanil.

Treatment:

Drug: Remifentanil

Drug: Ketamine 2