Remifentanil Requirement for Acceptable Intubating Condition

A

Ajou University School of Medicine

Status and phase

Completed
Phase 4

Conditions

Intubating Condition

Treatments

Drug: Ketamine 1
Drug: Ketamine 2
Drug: Remifentanil

Study type

Interventional

Funder types

Other

Identifiers

NCT02655380
MED-DRU-15-354

Details and patient eligibility

About

Ketamine and opioid are known to improve the intubating condition, respectively. Combination of ketamine and opioid potentiate analgesic effect and give hemodynamic stability in complementary manner. Therefore, the combination use of ketamine and remifentanil could be useful for acceptable intubating condition in the general anesthesia without the use of neuromuscular blocking agent. Generally, induction dose of ketamine ranges between 1 and 2 mg. There was no report about the optimal dose of remifentanil with 1 or 2 mg ketamine induction dose for intubation without neuromuscular blocking agent. The investigators focus on remifentanil dose using Dixon's up and down method.

Enrollment

51 patients

Sex

All

Ages

3 to 12 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • ASA I-II
  • Undergoing general anesthesia with endotracheal tube

Exclusion criteria

  • Anticipated difficult airway
  • Patient with upper respiratory infection within 14 days
  • Asthma

Trial design

Primary purpose

Supportive Care

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

51 participants in 2 patient groups

ketamine 1
Experimental group
Description:
Anesthesia induction with ketamine 1 mg followed by remifentanil.
Treatment:
Drug: Remifentanil
Drug: Ketamine 1
ketamine 2
Experimental group
Description:
Anesthesia induction with ketamine 2 mg followed by remifentanil.
Treatment:
Drug: Remifentanil
Drug: Ketamine 2

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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