Remifentanil Versus Sufentanil for Intubation Condition Without Myorelaxant (REMIDENT)

Toulouse University Hospital

Status and phase: Completed; Phase 4

Conditions: Anaesthetic Induction

Treatments: Drug: Remifentanyl - sufentanil placebo; Drug: Sufentanil - remifentanyl placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT01910285

HAO (Other Identifier)

12 522 03

Details and patient eligibility

About

The main objective is the comparison of intubation conditions after anesthetic induction bolus of propofol-sufentanil when compared to injection of propofol-remifentanil in patients undergoing surgery for tooth extraction.

Intubation without myorelaxant with propofol and sufentanil is classic but less efficient than induction with curare on achieving perfect intubation conditions. The use of a protocol without curare is sometimes justified for short gestures or when you want to avoid allergia. Remifentanil often provides excellent intubation conditions without myorelaxant. However, remifentanil was never compared to sufentanil in terms of intubating conditions without muscle relaxant.

Enrollment: 70 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients 18 to 60 years
• American Society of Anesthesiology (ASA) 1 or 2
• scheduled for surgical tooth extraction under general anesthesia with intubation
• signed consent form

Exclusion criteria

• criterion of difficult ventilation or intubation
• chronic alcoholism or opiate use
• beta-blockers or calcium channel blockers treatment
• allergy to paracetamol or ketoprofen
• patient under protection of justice

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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70 participants in 2 patient groups

Remifentanyl- sufentanil placebo

Experimental group

Description:

3 mg/kg of propofol combined with 3 µg/kg of remifentanil

Treatment:

Drug: Remifentanyl - sufentanil placebo

Sufentanil - remifentanyl placebo

Active Comparator group

Description:

3 mg/kg of propofol combined with 0.3 mg/kg of sufentanil

Treatment:

Drug: Sufentanil - remifentanyl placebo