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Remifentanil Versus Sufentanil for Intubation Condition Without Myorelaxant (REMIDENT)

T

Toulouse University Hospital

Status and phase

Completed
Phase 4

Conditions

Anaesthetic Induction

Treatments

Drug: Remifentanyl - sufentanil placebo
Drug: Sufentanil - remifentanyl placebo

Study type

Interventional

Funder types

Other

Identifiers

NCT01910285
HAO (Other Identifier)
12 522 03

Details and patient eligibility

About

The main objective is the comparison of intubation conditions after anesthetic induction bolus of propofol-sufentanil when compared to injection of propofol-remifentanil in patients undergoing surgery for tooth extraction.

Intubation without myorelaxant with propofol and sufentanil is classic but less efficient than induction with curare on achieving perfect intubation conditions. The use of a protocol without curare is sometimes justified for short gestures or when you want to avoid allergia. Remifentanil often provides excellent intubation conditions without myorelaxant. However, remifentanil was never compared to sufentanil in terms of intubating conditions without muscle relaxant.

Enrollment

70 patients

Sex

All

Ages

18 to 60 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • patients 18 to 60 years
  • American Society of Anesthesiology (ASA) 1 or 2
  • scheduled for surgical tooth extraction under general anesthesia with intubation
  • signed consent form

Exclusion criteria

  • criterion of difficult ventilation or intubation
  • chronic alcoholism or opiate use
  • beta-blockers or calcium channel blockers treatment
  • allergy to paracetamol or ketoprofen
  • patient under protection of justice

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

70 participants in 2 patient groups

Remifentanyl- sufentanil placebo
Experimental group
Description:
3 mg/kg of propofol combined with 3 µg/kg of remifentanil
Treatment:
Drug: Remifentanyl - sufentanil placebo
Sufentanil - remifentanyl placebo
Active Comparator group
Description:
3 mg/kg of propofol combined with 0.3 mg/kg of sufentanil
Treatment:
Drug: Sufentanil - remifentanyl placebo

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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