Remineralization Effect of βTricalcium Phosphate Nanoparticles Versus FunctionalizedβTricalcium Phosphate Nanoparticles

Aya Magdy Elsadany

Status: Completed

Conditions: White Spot Lesions[Initial Caries]on Smooth Surface of Tooth

Treatments: Other: Nano ᵦ tricalcium phosphate particles; Other: sodium fluoride mouth wash; Other: Functionalized Nano ᵦ tricalcium phosphate particles

Study type: Interventional

Funder types: Other

Identifiers

NCT06561789

#-P-OH-8-22-10

Details and patient eligibility

About

The study collects Sixty non carious sound human permanent premolars from Tanta University's maxillofacial surgery department. The teeth are cleaned and prepared, and randomly assigned into four groups. The specimens are analyzed using an EDX analysis scanning electron microscope, and surface micro-hardness is determined using a Digital Display Vickers Micro-hardness Tester.

Full description

The study involves collecting Sixty non carious sound human permanent premolars from an outpatient clinic at Tanta University's maxillofacial surgery department. The teeth are selected for their absence of caries, hypocalcification restoration, fracture fluorosis, and cracks. The teeth are cleaned and prepared for the study, including demineralization and artificial incipient enamel carious lesion preparation. The teeth are randomly assigned into four groups: functionalized Nano ᵦ tricalcium phosphate particles, Nano ᵦ tricalcium phosphate particles, sodium fluoride mouth wash, and artificial saliva. The pH of all groups is adjusted at 7. The specimens are treated in a daily pH cycling regime, with daily solution replacements. The specimens are then dried and analyzed using an Energy Dispersive X-Ray (EDX) analysis scanning electron microscope. The element content distribution of calcium and phosphorus elements is measured, and the specimens are evaluated at base line, after demineralization, and after 2, 4, and 6 weeks. Surface micro-hardness is determined using a Digital Display Vickers Micro-hardness Tester.

Data will be collected, presented, and statistically analyzed using SPSS software package system using ANOVA at a significance level of 0.05.

Enrollment: 60 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• The selected teeth were free from caries, hypocalcification restoration, fracture fluorosis and cracks

Exclusion criteria

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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60 participants in 4 patient groups

Functionalized Nano ᵦ tricalcium phosphate particles

Experimental group

Description:

The intervention is a prepared mouth wash solution for remineralization of demineralized enamel by investigator at Nano Gate institute (Egypt,cairo,elmokatm)

Treatment:

Other: Functionalized Nano ᵦ tricalcium phosphate particles

Nano ᵦ tricalcium phosphate particles

Experimental group

Description:

The intervention is a prepared mouth wash solution for remineralization of demineralized enamel by investigator at Nano Gate institute(Egypt,cairo,elmokatm)

Treatment:

Other: Nano ᵦ tricalcium phosphate particles

sodium fluoride mouth wash

Experimental group

Description:

The intervention is mouth wash solution for remineralization of demineralized enamel from Oral-B company

Treatment:

Other: sodium fluoride mouth wash

artifacial saliva

No Intervention group

Description:

it is an artificial solution that is mimic to human saliva prepared by investigator at faculty of pharmacy Tanta university