Remineralization Efficacy of Gum Arabic Varnish.

Cairo University (CU)

Status and phase: Unknown; Phase 3; Phase 2

Conditions: Remineralization; Caries,Dental; White Spot Lesion

Treatments: Drug: MI Varnish,GC Japan Inc.; Drug: Proflourid Varnish,VOCO; Drug: Gum Arabic varnish

Study type: Interventional

Funder types: Other

Identifiers

NCT04422860

CEBD-2

Details and patient eligibility

About

The aim of this study is to evaluate the remineralizing capacity of Gum Arabic varnish and its implementation into clinical practice.

Enrollment: 90 estimated patients

Sex: All

Ages: 17 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with initial carious lesions.
• Proper Oral hygiene.

Exclusion criteria

• Patients with a compromised medical history.
• Patients with active severe periodontal disease.
• Patients with hypoplastic or hypomineralized teeth.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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90 participants in 3 patient groups

Gum Arabic varnish

Experimental group

Description:

Gum arabic (Acacia senegal) is an exudate obtained from Acacia senegal stems and roots, and other similar African Acacia species. It consists mainly of high molecular weight polysaccharides high concentrations of calcium, magnesium, and potassium salts which can potentially increase tooth remineralization.

Treatment:

Drug: Gum Arabic varnish

Sodium Fluoride varnish

Active Comparator group

Description:

The gold standard remineralizing agent recommended by the guidelines.

Treatment:

Drug: Proflourid Varnish,VOCO

10% w/v CPP-ACP, 5% sodium fluoride varnish

Active Comparator group

Description:

CPP-ACP is the most studied non fluoride remineralizing agent.

Treatment:

Drug: MI Varnish,GC Japan Inc.