Remineralization of Dentine Caries Using Two Remineralizing Agents Which Are Nanosilver Fluoride and Casein phosphopeptides_amorphous Calcium Phosphate

University of Baghdad

Status: Unknown

Conditions: Dental Caries

Treatments: Other: Sodium fluoride with casein phosphopeptides amorphous calcium phosphate; Other: Sodium fluoride varnish; Other: Nanosilver fluoride

Study type: Interventional

Funder types: Other

Identifiers

NCT04930458

Dentine caries remineralizatio

Details and patient eligibility

About

The study is randomized controlled trial ...The null hypothesis suggests that there is no significant difference between nanosilver fluoride and sodium fluoride with Casein phosphopeptides_amorphous calcium phosphate in the remineralization of dental caries.

Full description

the patients will be randomly assigned to one of three study groups the first group is nanosilver fluoride,the second is casein phosphopeptides_amorphous calcium phosphate and the third is sodium fluoride as positive control..the three material will be applied in single application with no repetition ..follow up after one and three month ..the patient should have at least one carious lesion(ICDASII code 5)

Enrollment: 135 estimated patients

Sex: All

Ages: 6 to 12 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

• Clinical diagnosis of carious lesion
• participants should be free of any systemic diseases.

Exclusion Criteria:

• sensitivity to Silver or other heavy-metal ions or any milk-related allergies and medical conditions involving the kidneys.
• The tooth was excluded if it had pulp exposure, abscess/fistula, sensitivity to percussion

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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135 participants in 3 patient groups

Nanosilver fluoride group

Experimental group

Description:

Nanosilver fluoride will be applied on carious lesion

Treatment:

Other: Nanosilver fluoride

Sodium fluoride with casein phosphopeptides_Amorphous calcium phosphate group

Active Comparator group

Description:

Sodium fluoride with casein phosphopeptides_Amorphous calcium phosphate will be applied on carios lesion

Treatment:

Other: Sodium fluoride with casein phosphopeptides amorphous calcium phosphate

Sodium fluoride varnish group

Active Comparator group

Description:

Sodium fluoride varnish will be applied on carios lesion

Treatment:

Other: Sodium fluoride varnish