Remineralization Potential of Pearl Powder Compared to CPP-ACP on Enamel White Spot Lesions

Cairo University (CU)

Status and phase: Unknown; Phase 2

Conditions: White Spot Lesion

Treatments: Other: Pearl powder; Drug: Cpp-Acp

Study type: Interventional

Funder types: Other

Identifiers

NCT03976583

1081988

Details and patient eligibility

About

The aim of this study is to evaluate the remineralization potential of pearl powder on early ('white spot') lesions in enamel in orthodontic patients compared to casein phosphopeptide-amorphous calcium phosphate.

Full description

The aim of this study is to evaluate the remineralization potential of pearl powder on early ('white spot') lesions in enamel in orthodontic patients compared to casein phosphopeptide-amorphous calcium phosphate. The remineralisation potential will be assessed both visually and by standardised photographic image analysis. the follow up will be up to 12 months.

Enrollment: 62 estimated patients

Sex: All

Ages: 12 to 25 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Males or females.
• Age: 12-25 years old.
• Patients with good oral hygiene.
• Co-operative patients who show interest to participate in the study.

Exclusion criteria

• Patients with bad oral hygiene.
• Lack of patient's approval and compliance.
• Presence of abnormal oral, medical, or mental condition.
• Patients who are allergic to milk products.
• Pregnant and lactating women.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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62 participants in 2 patient groups

Cpp-acp

Active Comparator group

Description:

MI paste Self-administration of the product by the patient once in the evening. A pea-size amount of the product should be applied per arch, using a dry finger or cotton pellet to distribute it evenly across all teeth and to work it into the interdental spaces. The product was then retained in the mouth for 1-3 min, and manipulated around the teeth using the tongue, before being expectorated and patient should not rinse it until 30 min.

Treatment:

Drug: Cpp-Acp

Pearl powder

Experimental group

Description:

Pure pearl powder in the form of gel Self-administration of the product should be used once daily (in the evening), after a 2 min manual tooth brushing. .Participants were explicitly instructed to apply the gel by his finger allover the teeth and not to rinse their mouths after application and not to eat or drink for at least 30 min.

Treatment:

Other: Pearl powder