Remineralizing Potential of Biomimetic Scaffolds on Enamel White Spot Lesions

Hams Hamed Abdelrahman

Status: Not yet enrolling

Conditions: White Spot Lesion

Treatments: Other: CCP-ACP " +ve control " Casein phosphopeptide amorphous calcium phosphate; Other: Ph-chi phosphorylated - nano-chitosan; Other: Curodont repair Self- assembling peptide P11-4

Study type: Interventional

Funder types: Other

Identifiers

NCT05584878

biomimetic scaffolds _2022

Details and patient eligibility

About

The modern concept in caries treatment focuses on the non-invasive approach and on the biomimetic remineralization of early non-cavitated white spot carious lesions. Recently developed biomimetic scaffolds attempt to remineralize the dental tissues and are more regenerative than reparative.

Enrollment: 63 estimated patients

Sex: All

Ages: 18 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who at least have 1 white spot lesion.
• No systemic diseases or taking any medication affecting salivary flow.
• Patients with good oral hygiene measures.
• Patients with moderate caries risk assessment.
• Post orthodontic WSLs with International Caries Detection and Assessment System (ICDAS II) scoring criteria (1-2).

Exclusion criteria

• Participant in another trial.
• Developmental non carious lesion (enamel hypoplasia and dental fluorosis).
• Presence of abnormal oral disease, or medically compromised patients.
• Participants who had evidence of reduced salivary flow or significant tooth wear.
• Allergy to milk products or other drug allergies.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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63 participants in 3 patient groups

Group I

Experimental group

Treatment:

Other: Curodont repair Self- assembling peptide P11-4

Group II

Experimental group

Treatment:

Other: Ph-chi phosphorylated - nano-chitosan

Group III

Active Comparator group

Treatment:

Other: CCP-ACP " +ve control " Casein phosphopeptide amorphous calcium phosphate