Remote Exercise and Nutritional Prehabilitation for Pancreatic Cancer

H. Lee Moffitt Cancer Center and Research Institute

Status: Enrolling

Conditions: Pancreatic Cancer

Treatments: Behavioral: Resistance Training; Behavioral: Nutrition Counseling; Behavioral: Physical Activity

Study type: Interventional

Funder types: Other

Identifiers

NCT06423963

MCC-23088

Details and patient eligibility

About

The purpose of the study is to examine the feasibility and acceptability of an exercise and nutrition "prehabilitation" program for patients preparing for pancreatic cancer resection (removal).

Enrollment: 26 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18 years or older
• Biopsy-proven pancreatic ductal adenocarcinoma (PDAC), borderline resectable at diagnosis
• Eastern Cooperative Oncology Group (ECOG) performance status 0-2
• Undergoing neoadjuvant chemotherapy with treatment plan including chemoradiation therapy and surgical resection
• Ability to read and speak English

Exclusion criteria

• Regular engagement in RT (2x/week targeting all major muscle groups)
• Screen failure for exercise safety based on PAR-Q
• Underlying unstable cardiac or pulmonary disease or symptomatic cardiac disease
• Recent fracture or acute musculoskeletal injury that precludes ability to participate in RT
• Numeric pain rating scale greater than or equal to a 7 out of 10
• Myopathic or rheumatologic disease that impacts physical function

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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26 participants in 2 patient groups

Physical activity, nutrition counseling and monitoring group (PA/N)

Experimental group

Treatment:

Behavioral: Nutrition Counseling

Behavioral: Physical Activity

Physical activity, tele-resistance training, nutrition counseling and monitoring group (RT/N)

Experimental group

Treatment:

Behavioral: Nutrition Counseling

Behavioral: Physical Activity

Behavioral: Resistance Training