Remote Ischemia Precondition (RIPC) for Hepatic Protection in Patients Undergoing Hepatectomy

Naval Military Medical University (Second Military Medical University)

Status: Unknown

Conditions: Liver Neoplasms

Treatments: Other: None remote ischemia precondition; Other: Remote ischemia precondition

Study type: Interventional

Funder types: Other

Identifiers

NCT02168608

EHBHKY2013-003-006

Details and patient eligibility

About

Remote ischemia precondition could protect the liver from ischemia reperfusion injury in patients undergoing hepatectomy.

Full description

Remote ischemia precondition (RIPC) had been proofed beneficial to ischemia reperfusion injury of heart, kidney, liver, brain and spinal cord in experimentation on animals. And the clinical studies of RIPC were mainly focused on heart, RIPC's protection effect on hepatic ischemia reperfusion injury in patients undergoing hepatectomy still remains unknown, So we designed this study to demonstrate the hypotheses.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• No other main organ diseases, American society of Anesthesiologists (ASA) classification Ⅰ-Ⅱ grade
• Selective hepatectomy, one time hepatic portal occlusion
• Child-Pugh A

Exclusion criteria

• Peripheral vessels diseases
• Not the same surgical procedure as expected
• Administered anti-inflammatory drugs as glucocorticoid etc
• Diagnosed of diabetes
• History of liver surgery
• History of hepatic interventional therapy, radiofrequency therapy,radiotherapy and chemotherapy
• Refuse to join the research
• Patients with psychopathy
• Acute infection need antibiotic therapy
• Hepatic artery or portal vein embolism

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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100 participants in 2 patient groups

Remote ischemia precondition

Experimental group

Description:

patients in this arm accepted RIPC procedure after induction of anesthesia

Treatment:

Other: Remote ischemia precondition

None remote ischemia precondition

Experimental group

Description:

patients in this arm didn't accept RIPC procedure after induction of anesthesia

Treatment:

Other: None remote ischemia precondition