Remote Ischemic Conditioning and Platelet Dysfunction

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Seoul National University

Status

Completed

Conditions

Platelet Function

Treatments

Procedure: Control
Procedure: Remote ischemic conditioning

Study type

Interventional

Funder types

Other

Identifiers

NCT03125681
RIPC_multiplate

Details and patient eligibility

About

The purpose of this study is to evaluate the effects of remote ischemic conditioning on platelet function during off-pump coronary artery bypass surgery.

Full description

Remote ischemic conditioning (RIC) may affect platelet function. However, little is known about effect of RIC on platelet function during off-pump coronary artery bypass surgery. In this study investigators are going to perform RIC after anesthesia induction (remote ischemic pre-conditioning) and after completion of coronary anastomoses (remote ischemic post-conditioning), and compare platelet function parameters with control group.

Enrollment

58 patients

Sex

All

Ages

20 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

20 - 80 years of adult patient undergoing elective off-pump coronary artery bypass surgery

Exclusion criteria

  • Acute Myocardial Infarction
  • Recent (<1 month) coronary angioplasty (percutaneous coronary intervention, PCI)
  • Acute cerebrovascular ischemia (<6 months)
  • Preoperative LV EF < 30%, mechanical ventricular support (IABP, VAD, ECMO)
  • Peripheral vascular disease
  • Poorly controlled diabetes mellitus
  • Alzheimer's disease
  • NSAIDs within 3 days
  • iv heparin within 6 h
  • low molecular weight heparin within 24 h
  • platelet inhibitor within 24 h
  • known thrombocytopenia
  • renal failure / hemodialysis
  • active infection
  • preoperative bleeding diathesis
  • redo-operation
  • pregnancy

Trial design

58 participants in 2 patient groups, including a placebo group

Remote ischemic conditioning
Experimental group
Description:
Applying pneumatic cuff on upper extremity (5 minutes cycles of limb ischemia and reperfusion with pneumatic cuff up to 200 mmHg repeated by four times) before and after coronary anastomoses.
Treatment:
Procedure: Remote ischemic conditioning
Control
Placebo Comparator group
Description:
All the procedures were the same in the control group, except for the fact that the three-way stopcock between the pneumatic cuff and the cuff inflator was opened and therefore the cuff pressure did not increase.
Treatment:
Procedure: Control

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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