Remote Ischemic Conditioning and Platelet Dysfunction

Seoul National University

Status: Completed

Conditions: Platelet Function

Treatments: Procedure: Control; Procedure: Remote ischemic conditioning

Study type: Interventional

Funder types: Other

Identifiers

NCT03125681

RIPC_multiplate

Details and patient eligibility

About

The purpose of this study is to evaluate the effects of remote ischemic conditioning on platelet function during off-pump coronary artery bypass surgery.

Full description

Remote ischemic conditioning (RIC) may affect platelet function. However, little is known about effect of RIC on platelet function during off-pump coronary artery bypass surgery. In this study investigators are going to perform RIC after anesthesia induction (remote ischemic pre-conditioning) and after completion of coronary anastomoses (remote ischemic post-conditioning), and compare platelet function parameters with control group.

Enrollment: 58 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 20 - 80 years of adult patient undergoing elective off-pump coronary artery bypass surgery

Exclusion criteria

• Acute Myocardial Infarction
• Recent (<1 month) coronary angioplasty (percutaneous coronary intervention, PCI)
• Acute cerebrovascular ischemia (<6 months)
• Preoperative LV EF < 30%, mechanical ventricular support (IABP, VAD, ECMO)
• Peripheral vascular disease
• Poorly controlled diabetes mellitus
• Alzheimer's disease
• NSAIDs within 3 days
• iv heparin within 6 h
• low molecular weight heparin within 24 h
• platelet inhibitor within 24 h
• known thrombocytopenia
• renal failure / hemodialysis
• active infection
• preoperative bleeding diathesis
• redo-operation
• pregnancy

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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58 participants in 2 patient groups, including a placebo group

Remote ischemic conditioning

Experimental group

Description:

Applying pneumatic cuff on upper extremity (5 minutes cycles of limb ischemia and reperfusion with pneumatic cuff up to 200 mmHg repeated by four times) before and after coronary anastomoses.

Treatment:

Procedure: Remote ischemic conditioning

Control

Placebo Comparator group

Description:

All the procedures were the same in the control group, except for the fact that the three-way stopcock between the pneumatic cuff and the cuff inflator was opened and therefore the cuff pressure did not increase.

Treatment:

Procedure: Control