Remote Ischemic Conditioning in STEMI to Decrease Infarct Size (RemCon-STEMI)

University of Alberta

Status: Completed

Conditions: CAD; STEMI

Treatments: Procedure: Remote Ischemic conditioning; Other: Standard of care

Study type: Interventional

Funder types: Other

Identifiers

NCT03930589

V1 November 15, 2013

Details and patient eligibility

About

Following acute STEMI patients may have significant myocardial damage and subsequent heart failure. There is currently conflicting data regarding the benefit of remote ischemic conditioning to decrease the magnitude of infarction. Remote ischemic condition is a process where by repetitive intermittent limb ischemia is used to decrease the magnitude of myocardial damage caused by coronary artery occlusion and the subsequent reperfusion injury in STEMI patients. RemCon-STEMI is a multicenter randomized trial to test the impact of remote ischemic conditioning in acute STEMI.

Enrollment: 251 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Patients presenting with STEMI within 6 hours of symptom onset and:

1. Are expected to receive reperfusion therapy with either fibrinolysis or primary PCI.
2. Documented informed consent (verbal)

Exclusion criteria

1. Cardiogenic shock
2. History of anatomical deformity or vascular complication that limit ability to conduct remote ischemic preconditioning

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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251 participants in 2 patient groups, including a placebo group

Standard of care

Placebo Comparator group

Description:

no intervention will occur in the standard of care arm

Treatment:

Other: Standard of care

Remote Ischemic Conditioning

Active Comparator group

Description:

Remote ischemic conditioning using BP cuff on left arm

Treatment:

Procedure: Remote Ischemic conditioning