Remote Ischemic Limb Preconditioning In Healthy Volunteers

University of Miami

Status: Completed

Conditions: Stroke; Cerebrovascular Disease

Treatments: Procedure: 3x 10min Sham Preconditioning; Procedure: 3x 10min Limb Preconditioning; Procedure: 4x 5min Limb Preconditioning

Study type: Interventional

Funder types: Other

Identifiers

NCT02553655

20150648

Details and patient eligibility

About

The investigators would like to determine if remote ischemic leg preconditioning in healthy volunteers improves cerebral vasomotor reactivity as measured by breath holding and transcranial doppler vasomotor reactivity.

Full description

This study is to determine if remote ischemic leg preconditioning improves short and long term cerebral vasomotor reactivity in healthy volunteers as measured by breath holding and transcranial doppler vasomotor reactivity. Previous studies on brachial vasomotor reactivity have shown a beneficial effect of remote ischemic preconditioning. It remains uncertain if a similar beneficial effect can be reproduced with cerebral vasomotor testing. Many biological mechanisms and effector pathways triggered by preconditioning have demonstrated endothelial protection and beneficial vascular effects.

Enrollment: 17 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers

Exclusion criteria

• Presence of chronic medical conditions such as diabetes, hypertension, cardiac disease etc.
• Any prescribed medication
• Pregnancy [by history and last menstrual period]
• Any leg injury that would, in the opinion of the investigator, affect preconditioning

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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17 participants in 3 patient groups

4x 5min Limb Preconditioning

Active Comparator group

Description:

Either the right or left leg of the participant(s) will be made transiently ischemic for 5 minutes following by 5 minutes of rest. This will be repeated for 4 times.

Treatment:

Procedure: 4x 5min Limb Preconditioning

3x 10min Limb Preconditioning

Active Comparator group

Description:

Either the right or left leg of the participant(s) will be made transiently ischemic for 10 minutes following by 5 minutes of rest. This will be repeated for 3 times.

Treatment:

Procedure: 3x 10min Limb Preconditioning

3x 10min Sham Preconditioning

Sham Comparator group

Description:

Either the right or left leg of the participant(s) will be squeezed without causing ischemia for 10 minutes following by 5 minutes of rest. This will be repeated for 3 times.

Treatment:

Procedure: 3x 10min Sham Preconditioning