Remote Ischemic Preconditioning During Lower Limb Revascularization

University of Messina

Status: Completed

Conditions: Acute Kidney Injury; Limb Ischemia; Ischemic Preconditioning

Treatments: Procedure: RIPC; Procedure: Control

Study type: Interventional

Funder types: Other

Identifiers

NCT04016857

UMEANE1

Details and patient eligibility

About

The aim of this study is to evaluate the role of remote ischemic preconditioning (RIPC) in preventing acute kidney injury after lower limb revascularization.

Remote ischemic preconditioning(RIPC) is a simple, cost-free and non invasive procedure (transient upper limb ischemia/reperfusion) that could provide organ protection (Heart, Brain and Kidney) following ischemia injuries.

Enrollment: 50 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients scheduled for open limb revascularization

Exclusion criteria

• Peripheral vascular disease affecting upper limbs
• Chronic kidney disease in stage 4 or 5 (eGFR<30 ml/min/1,73m2)
• Patients underwent contrast-enhanced radiological exams in the previous 7 days
• Treatment with glibencamide or prostaglandins

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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50 participants in 2 patient groups

RIPC Group

Experimental group

Description:

Remote ischemic preconditioning

Treatment:

Procedure: RIPC

Control Group

Sham Comparator group

Description:

Sham remote ischemic preconditioning

Treatment:

Procedure: Control