Remote Ischemic Preconditioning in Liver Transplantation (RIRI)

Mansoura University

Status: Unknown

Conditions: Liver Transplanatation

Treatments: Procedure: Ischemia preconditioining

Study type: Interventional

Funder types: Other

Identifiers

NCT02534025

1/2015

Details and patient eligibility

About

Remote (upper arm) ischemic preconditioning in the donor of living donor liver transplanta to ameliorate the effect of reperfusion injury in recipients.

Full description

Upper arm ischemia will be induced by elevation of NIBP cuff pressure to 200 mm Hg for 5 minutes repeated four times 5 mniutes apart, aiming to decrease the effect of ischemia reperfusion in the graft liver.

Enrollment: 100 estimated patients

Sex: All

Ages: 30 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All candidates for living donor liver transplantation

Exclusion criteria

• Donors with peripheral vascular disease

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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100 participants in 2 patient groups

P group

Experimental group

Description:

Elevation of Cuff pressure to 200 mm Hg for 5 minutes four times 5 minutes apart

Treatment:

Procedure: Ischemia preconditioining

C group

No Intervention group

Description:

no intervention will be added to routine anesthetic mangement