Remote Ischemic Preconditioning Induces Myocardial RISK Signaling Pathway in Patients Undergoing Valvular Heart Surgery

Yonsei University

Status and phase: Completed; Phase 4

Conditions: Patients With Elective Aortic Valve Replacement

Treatments: Procedure: Remote ischemic preconditioning at left upper arm; Procedure: Control group

Study type: Interventional

Funder types: Other

Identifiers

NCT01946087

4-2012-0283

Details and patient eligibility

About

The aim of this study is to investigate whether RIPC protects the heart against ischemia reperfusion injury on the concentrically hypertrophied myocardium

Enrollment: 79 patients

Sex: All

Ages: 20 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients aged ≥20 years with severe degenerative AS presenting concentric remodeling of the LV, who were scheduled for AVR

Exclusion criteria

• diabetes mellitus,
• coronary stenosis ≥70%,
• renal failure (serum creatinine > 2.0 mg/dL),
• upper arm peripheral vascular disease,
• LV ejection fraction <50%

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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79 participants in 2 patient groups, including a placebo group

RIPC group

Experimental group

Treatment:

Procedure: Remote ischemic preconditioning at left upper arm

Control group

Placebo Comparator group

Treatment:

Procedure: Control group