Remote Ischemic Preconditioning of Dynamic Cerebral Autoregulation in Healthy Adults (RIPCA)

Yi Yang

Status: Completed

Conditions: Ischemic Preconditioning

Treatments: Procedure: dCA measurement; Procedure: Intravenous blood collection; Device: Remote ischemic conditioning equipment

Study type: Interventional

Funder types: Other

Identifiers

NCT02965547

RIPCA

Details and patient eligibility

About

The purpose of this study is to determine the impact of remote ischemic preconditioning on dynamic cerebral autoregulation and related hematology indexes in healthy adults.

Full description

Remote ischemic preconditioning(RIPC) is the phenomenon whereby brief cycles of ischemia and reperfusion, applied to a distant organ, provide protection to the target organ. Dynamic cerebral autoregulation(dCA), a mechanism to maintain the cerebral blood flow, has been proved to be critical for the occurrence,development and prognosis of ischemic neurovascular disease. In this study, we hypothesis that RIPC provides neuro-protection by means of improving dCA.

Enrollment: 50 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age from 18 to 70,both genders
• Willing to participate in follow-up visits

Exclusion criteria

• current or having a history of chronic physical diseases or mental diseases
• suffering from infectious diseases in late one month
• pregnant and lactating women；
• smoking or drinking；
• inability to cooperate sufficiently to complete the dCA examination

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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50 participants in 1 patient group

RIPC Group

Experimental group

Description:

RIPC was induced by 4 cycles of extremities ischemia (5-minute blood-pressure cuff inflation to 200 mm Hg, followed by 5-minute cuff deflation).All subjects will take RIPC intervention, blood collection and 7 dCA measurements.

Treatment:

Device: Remote ischemic conditioning equipment

Procedure: dCA measurement

Procedure: Intravenous blood collection