Remote Ischemic Preconditioning With Postconditioning in Heart Transplantation Surgery

Chinese Academy of Medical Sciences, Fuwai Hospital

Status: Completed

Conditions: Cardiomyopathy; End Stage Heart Disease; Myocardial Ischemic Reperfusion Injury; Heart Failure

Treatments: Procedure: RIPC+RIPostC; Procedure: control

Study type: Interventional

Funder types: Other

Identifiers

NCT02149316

FW2012-863B-C

Details and patient eligibility

About

The purpose of this study is to determine whether remote ischemic preconditioning with postconditioning (RIPC+RIPostC) reduces myocardial injury and improves clinical outcomes in heart transplantation surgery.

Enrollment: 60 patients

Sex: All

Ages: 14 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• scheduled for elective orthotopic heart transplantation surgery

Exclusion criteria

• peripheral vascular disease affecting the upper arms
• mechanical circulatory support before surgery
• taking the antidiabetic sulphonylurea, glibenclamide
• cold ischemic time of donor heart > 12 hours
• repeated heart surgery

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups

RIPC+RIPostC

Experimental group

Treatment:

Procedure: RIPC+RIPostC

control

Sham Comparator group

Treatment:

Procedure: control