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Remote Sensing for ADRD-Specific Activities Identification in Older Adults

University of Missouri (MU) logo

University of Missouri (MU)

Status

Enrolling

Conditions

Mild Cognitive Impairment (MCI)
Alzheimer Disease and Related Dementias (ADRD)

Treatments

Other: Remote Ambient Sensor System

Study type

Interventional

Funder types

Other

Identifiers

NCT07120347
2101666
24AARGD-NTF-1242722 (Other Grant/Funding Number)

Details and patient eligibility

About

The investigators aim to use smart-home sensors and artificial intelligence (AI) to monitor and detect Alzheimer's Disease and Related Dementias (ADRD)-specific daily activities among older adults, with the goal of early symptom detection and personalized support. Dementia, which impacts memory and cognition, remains a global concern. In the United States, more than 6.7 million individuals aged 65 and older are living with ADRD, and projected annual healthcare costs are expected to reach $1 trillion by 2050. This underscores the need for deeper understanding and innovative support. To address the unique challenges associated with ADRD, such as cognitive decline, personalized strategies that promote independent well-being are essential. Smart-home sensors can support older adults with ADRD as they continue to live in their homes. These sensors provide real-time data on health and daily activities, offering insights into their daily lives. However, adoption of these technologies is low, and the practical application of AI remains limited. This highlights the need for further research to make these devices more accessible to this population. The investigators' aims include:

Conducting focus groups with individuals with and without ADRD and their caregivers to identify daily activities that can be measured using in-home sensors; Collecting in-home sensor data from older adults with and without ADRD; and Using AI to develop a tool for recognizing daily activities. The integration of smart-home sensors with advanced data-analysis techniques holds significant potential for transforming the support and care provided to individuals with ADRD. Ultimately, the investigators' findings will contribute to improving the quality of life for affected individuals and alleviating the burden on caregivers and healthcare systems.

Full description

Dementia, which impacts memory and cognitive abilities, constitutes a global concern that intensifies with the aging population. In the United States, 6.7 million individuals aged 65 and older live with Alzheimer's Disease and Related Dementias (ADRD), and projected annual healthcare costs are expected to reach $1 trillion by 2050. This underscores the urgent need for enhanced understanding and innovative support. Individuals with ADRD face unique challenges, including behavioral changes and cognitive decline, necessitating tailored strategies for their well-being. Aligning with the National Institute on Aging's research goals, the investigators' study explores a promising avenue: the use of smart-home sensors to monitor and assist ADRD patients while they reside in their homes. These sensors provide real-time insights into health, activity, and environmental factors. However, adoption of these technologies among people with ADRD is low, and the practical application of artificial intelligence (AI) in this context remains limited. This underscores the need for further research to make these devices more accessible to this population.

The investigators aim to utilize a fully modular smart-home sensor system, combined with AI-based data-analysis methods, to monitor and analyze activities specific to individuals with ADRD. Remote sensor installations have been deployed across Missouri to facilitate the seamless delivery of sensor data to the investigators' interdisciplinary team, known as the Age-friendly Smart, Sustainable, and Equitable Technologies for Access intervention research team. The investigators' approach involves applying AI with causal inference to gain a nuanced understanding of the daily activities and behavioral patterns of those with ADRD. The investigators hypothesize that incorporating modeled causal features into the AI process will 1) enable identification of ADRD-specific daily activities, and 2) enhance the AI's ability to recognize these activities.

The investigators' aims include:

Conducting focus groups with individuals with and without ADRD and their caregivers to identify daily activities measurable with in-home sensors; Collecting in-home sensor data from older adults with and without ADRD; and Developing an AI system using machine-learning (ML) models for ADRD-specific daily activity recognition. Aim 3 will encompass three key elements: identification of causal features associated with ADRD-specific daily activities, development and refinement of ML models for recognizing these activities informed by the causal features, and creation of personalized ML models for individuals diagnosed with ADRD.

The integration of smart-home sensors with advanced data-analysis techniques holds significant potential for transforming the support and care provided to individuals with ADRD. Ultimately, the investigators' findings will contribute to improving the quality of life for affected individuals and alleviating the burden on caregivers and healthcare systems.

Enrollment

16 estimated patients

Sex

All

Ages

50+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

  • Community-dwelling, English-speaking adults aged ≥ 50 years
  • Clinical diagnosis of mild cognitive impairment or mild dementia (ADRD)
  • Diagnosis established by a neuropsychologist, neurologist, or geriatrician within the University of Missouri Healthcare System
  • Diagnosis confirmed using the latest consensus criteria and verified through record review
  • No restriction on the etiology of the cognitive disorder (e.g., Alzheimer's disease, vascular dementia, mixed dementia)

Exclusion Criteria

  • Clinical Dementia Rating (CDR) global score > 1 (moderate or severe dementia)
  • Cognitive or functional impairments that would preclude meaningful participation in daily activities

Trial design

Primary purpose

Supportive Care

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

16 participants in 2 patient groups

Pariticpants w/ ADRD
Experimental group
Treatment:
Other: Remote Ambient Sensor System
Participants w/o ADRD
Active Comparator group
Treatment:
Other: Remote Ambient Sensor System

Trial contacts and locations

1

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Central trial contact

Knoo Lee, PhD

Data sourced from clinicaltrials.gov

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