Remotely Administered Diet Intervention to Impact Symptom Burden in Myeloproliferative Neoplasm

University of California Irvine (UCI)

Status and phase

Completed

Phase 2

Conditions

Myeloproliferative Neoplasm

Treatments

Behavioral: Diet intervention

Study type

Interventional

Funder types

Other

Identifiers

NCT04744974

20-49 (Other Identifier)

2020-5932

Details and patient eligibility

About

Myeloproliferative Neoplasm (MPN) is a chronic blood cancer without cure. The major clinical issues in MPN are 1) an increased risk of blood clots 2) symptoms thought to be driven by chronic inflammation which in some cases can be debilitating and 3) progression to acute leukemia. The current management of MPN focuses on preventing blood clots and relieving symptoms. However, treatments that reduce symptoms such as JAK inhibitors are limited to late stage MPN patients and have significant side effects including immunosuppression, reduction in platelets, and increased risk of skin cancer. Therefore, low risk interventions are sorely needed for MPN patients that can reduce symptoms. Diet represents a low risk way to reduce inflammation, specifically a Mediterranean diet has been found to reduce inflammation in cardiovascular disease. There has been a recently completed clinical trial that demonstrated MPN patients can adopt a Mediterranean diet if given dietician counseling and curriculum. However, in order to reach a larger group of people a fully remotely administered study is necessary. This is a feasibility study to determine.

Enrollment

28 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age ≥18 with a diagnosis of a Philadelphia chromosome negative Myeloproliferative Neoplasm (MPN) including Essential Thrombocythemia (ET), Polycythemia Vera (PV), or Myelofibrosis (MF)
Has access to the internet and email
MPN-Total Symptom Score (MPN-TSS) score of ≥10 on screening survey
Mediterranean Adherence score of ≤10 on screening survey
English fluency (intervention requires conversations with study staff)
In the opinion of the study team is amenable to changing one's diet

Exclusion criteria

Pregnant or planning to become pregnant over the course of the study
Has food allergies, intolerances, or other dietary restrictions which would severely limit changes to their diet toward a Mediterranean style diet (such as allergies to ALL tree nuts or olive oil)