Removal of Beta Blocker Drugs by Hemodialysis

Lawson Health Research Institute

Status and phase: Completed; Phase 2; Phase 1

Conditions: Chronic Kidney Diseases

Treatments: Drug: Beta blocker

Study type: Interventional

Funder types: Other

Identifiers

NCT03361280

104909

Details and patient eligibility

About

Eight maintenance hemodialysis patients are given one of four beta blocker drugs (atenolol, bisoprolol, carvedilol, metoprolol) three hours prior to a hemodialysis session. Blood samples and spent dialysate are collected during dialysis. On separate dialysis sessions, patients received the other study drugs until they have taken each of the four study drugs. Dialytic clearance is calculated.

Enrollment: 8 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• at least 18 years of age, receiving hemodialysis three times per week for at least 90 days.

Exclusion criteria

• gastrointestinal or liver disease, body mass index greater than 40 kg/m2, contraindications for receiving a beta blocker (treatment with contraindicated medications, prior adverse reaction, severe reactive airway disease, hemodynamic instability during dialysis).

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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8 participants in 4 patient groups

Atenolol

Experimental group

Description:

Atenolol (50 mg) administered 3 hours prior to a hemodialysis session. Blood samples are collected a multiple times during dialysis and spent dialysate is collected at the end of the dialysis session.

Treatment:

Drug: Beta blocker

Bisoprolol

Experimental group

Description:

Bisoprolol (5 mg) administered 3 hours prior to a hemodialysis session. Blood samples are collected a multiple times during dialysis and spent dialysate is collected at the end of the dialysis session.

Treatment:

Drug: Beta blocker

Metoprolol

Experimental group

Description:

Metoprolol (50 mg) administered 3 hours prior to a hemodialysis session. Blood samples are collected a multiple times during dialysis and spent dialysate is collected at the end of the dialysis session.

Treatment:

Drug: Beta blocker

Carvedilol

Experimental group

Description:

Carvedilol (6.25 mg) administered 3 hours prior to a hemodialysis session. Blood samples are collected a multiple times during dialysis and spent dialysate is collected at the end of the dialysis session.

Treatment:

Drug: Beta blocker