Removal of mtDNA in Plasma by Continous Venovenous Hemofiltration in Sepsis

First People's Hospital of Chenzhou

Status: Unknown

Conditions: Intensive Care Unit

Treatments: Procedure: continous venovenous hemofiltraion

Study type: Interventional

Funder types: Other

Identifiers

NCT04083482

WYJ2019

Details and patient eligibility

About

The plasma level of mtDNA in sepsis is affected by continous venovenous hemofiltation（CVVH）

Full description

Continous renal replacement therapy （CRRT）has become routine for patients with chronic renal failure ，AKI，fliud overload as well as oliguria in ICU .In clinical patients ，continous venovenous hemofoiltration （CVVH）is actually the method of chioce for CRRT in critically ill and hemodynamic instable patients .CVVH has significant beneficial effects on removing inflammatory cytokines ，improving oxygen index，increasing cardiac index and regulating immune dysfuntion .

Enrollment: 20 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Adult septic patients undergoing CRRT

Exclusion criteria

1. Missing vists
2. transplatation
3. cancer
4. aquired immunodeficiency syndrome

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

Septic patients require CVVH

Experimental group

Description:

continuous venovenous hemofiltration. Continuous renal replacement therapy（CRRT）has become routine for patients with chronic renal failure ，AKI，fliud overload as well as oliguria in ICU .Continuous venovenous hemofiltration（CVVH）is the method of chioce for CRRT in critical ill .CVVH has significant beneficial effects on removing inflammatory cytokines ，improving oxygen index ，decreasing vasopressor requirements，increasing cardiac index and regulating immune dysfunction .

Treatment:

Procedure: continous venovenous hemofiltraion