Renal Acute MI Study

Monash University

Status: Completed

Conditions: Kidney Function; Myocardial Infarction

Study type: Observational

Funder types: Other

Identifiers

NCT01580566

CP-03/11

Details and patient eligibility

About

The purpose of this study is to determine if a sizable myocardial infarction (heart attack) results in negative changes to renal structure and function (i.e. has a negative impact on the kidneys).

To determine if the renal response to a myocardial infarction is a predictor of the patients future health.

Full description

Chronic heart and kidney disease are increasingly common in Western society. Both conditions are associated with frequent hospitalisation and increased mortality. Furthermore, there are mechanistic reasons why one condition may beget the other; the so-called "cardiorenal syndrome". The investigators therefore wish to determine if a sizable myocardial infarction (heart attack) results in negative changes to renal structure and function (i.e. has a negative impact on the kidneys). The investigators also wish to determine if the renal response to a myocardial infarction is a predictor of the patients future health. To do this the investigators will measure markers of kidney function at the time of the heart attach, at discharge, 1 month, 6 months and 12 months and correlate this with the patients clinical condition.

Enrollment: 50 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Age > 18 years

Have provided written informed consent

Group 1:

• Non-Q wave MI patients
• normal cardiac and renal function
• No use of contrast
• eGFR > 60ml/min

Group 2:

• Patients undergoing coronary angiography +/- PCI for stable CAD or non-Q wave MI
• normal cardiac and renal function
• eGFR > 60ml/min

Group 3:

• Acute STEMI Full thickness infarct (STEMI)
• eGFR ≥ 60ml/min

Group 4:

• Acute STEMI Full thickness infarct (STEMI)
• eGFR < 60ml/min

Exclusion criteria

• Unable or unwilling to comply with the study protocol
• Underlying medical condition which, in the opinion of the investigator, will effect the safely or efficacy of the study

Trial design

50 participants in 4 patient groups

Group 1 - Control

Description:

Non-Q wave MI subjects with normal cardiac and renal function (defined as eGFR \>60ml/min) not undergoing a cardiac procedure involving contrast will serve as "control" for renal injury subjects.

Group 2 - stable CAD or non-Q wave MI

Description:

Patients undergoing coronary angiography +/- PCI for stable CAD or non-Q wave MI with normal cardiac and renal function (defined as eGFR \>60ml/min) will control for the contrast STEMI patients are likely to receive as part of their post-MI management

Group 3 - Acute STEMI without chronic kidney disease

Description:

Acute STEMI patients (n=40), without chronic kidney disease (defined as eGFR ≥60ml/min).

Group 4 - Acute STEMI with kidney disease

Description:

Acute STEMI patients (n=40), with evidence of background chronic kidney disease (eGFR \<60ml/min).