Renal Biopsies in Post-liver Transplantation Patients With Renal Impairment

Shanghai Jiao Tong University

Status: Enrolling

Conditions: Liver Transplantation; Renal Insufficiency, Chronic

Treatments: Behavioral: renal biospy

Study type: Observational

Funder types: Other

Identifiers

NCT05326399

Renji20220326

Details and patient eligibility

About

Investigators will conduct this single-center, prospective cohort study to explore the prevalence and risk factors of renal function progression in post-liver transplantation patients with renal impairment after renal biospy and to understand the the pathology of kidney disease in post-liver transplantation patients with renal impairment.

Full description

This is a single-center, prospective, cohort study. This study will include approximate 369 post-liver transplantation patients with renal impairment and have received renal biopsy. Demographic characteristics, medical history, etiology of liver failure, concomitant medications, baseline laboratory parameters, etc., will be recorded. All participants will receive standard treatment by hepatologists and nephrologists based on the pathological results. All participants will be followed up for 96 weeks. Renal function, concomitant medications, and other laboratory parameters, etc., will be obtained.

Enrollment: 369 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age 18-75 years
• patients received liver transplantation
• new onset of proteinuria(defined as 24-hour proteinuria>1g/24h, or Urinary albumin creatinine ratio(UACR)>300mg/g at least two occasions
• have received renal biopsy in the past 3 months
• Signed informed consent form(ICF)

Exclusion criteria

• patients received renal transplantation
• hepatic failure
• severe bleeding risk or platelet <70*109/L
• chronic kidney insufficiency with eGFR<30ml/min·1.73m2,or kidney atrophy, or solitary kidney, or medullary sponge kidney, or polycystic kidney, or obstructive nephropathy
• uncontrolled mental disease or unable to cooperate during operation
• Pregnancy or lactation
• not suitable for this study judged by investigaters

Trial design

369 participants in 1 patient group

renal biopsy

Description:

Standard percutaneous biopsy has been performed in all participants. Light microscope, fluorescence microscope and electron microscope were used for assessment of kidney issue

Treatment:

Behavioral: renal biospy